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Bentham Science Publishers, Current Neuropharmacology, 4(10), p. 303-310

DOI: 10.2174/157015912804499465

Bentham Science Publishers, Current Neuropharmacology, 4(10), p. 303-310

DOI: 10.2174/157015912804143522

Bentham Science Publishers, Current Neuropharmacology, 4(10), p. 303-310

DOI: 10.2174/1570159x11209040303

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Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes

Journal article published in 2012 by Antonio Contestabile, Barbara Monti ORCID, Elisabetta Polazzi
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Nitric oxide (NO) is a versatile cellular messenger performing a variety of physiologic and pathologic actions in most tissues. It is particularly important in the nervous system, where it is involved in multiple functions, as well as in neuropathology, when produced in excess. Several of these functions are based on interactions between NO produced by neurons and NO produced by glial cells, mainly astrocytes and microglia. The present paper briefly reviews some of these interactions, in particular those involved in metabolic regulation, control of cerebral blood flow, axonogenesis, synaptic function and neurogenesis. Aim of the paper is mainly to underline the physiologic aspects of these interactions rather than the pathologic ones.