Published in
American Society of Hematology, Blood, 13(126), p. 1609-1620, 2015
DOI: 10.1182/blood-2015-01-622662
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Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
Journal article published in 2015 by
Kate H. Gartlan 
,
Kate A. Markey,
Antiopi Varelias,
Mark D. Bunting,
Motoko Koyama,
Rachel D. Kuns,
Neil C. Raffelt,
Stuart D. Olver,
Katie E. Lineburg,
Melody Cheong,
Bianca E. Teal,
Mary Lor,
Iain Comerford,
Michele W. L. Teng ,
Mark J. Smyth
and other authors.
,
Kate A. Markey,
Antiopi Varelias,
Mark D. Bunting,
Motoko Koyama,
Rachel D. Kuns,
Neil C. Raffelt,
Stuart D. Olver,
Katie E. Lineburg,
Melody Cheong,
Bianca E. Teal,
Mary Lor,
Iain Comerford,
Michele W. L. Teng ,
Mark J. Smyth
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Donor-derived Tc17 cells differentiate early after allogeneic transplant in response to IL-6 and alloantigen presentation by host DCs. Tc17 are highly proinflammatory and pathogenic posttransplant, but exert limited or no GVL activity.