Published in

International Union of Crystallography, Acta Crystallographica Section E: Structure Reports Online, 11(70), p. o1149-o1150, 2014

DOI: 10.1107/s1600536814021400

Links

Tools

Export citation

Search in Google Scholar

Crystallographic study of PET radiotracers in clinical evaluation for early diagnosis of Alzheimers

Journal article published in 2014 by Angela Altomare, Elena Capparelli, Antonio Carrieri, Nicola A. Colabufo, Anna Moliterni ORCID, Rosanna Rizzi, Dritan Siliqi
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The title compound, C24H25NO3·2CH3OH, which crystallized as a methanol disolvate, has applications as a PET radiotracer in the early diagnosis of Alzheimer's disease. The dihedral angle between the biphenyl rings is 8.2 (2)° and the heterocyclic ring adopts a half-chair conformation with the N atom adopting a pyramidal geometry (bond-angle sum = 327.6°). The C atoms of both methoxy groups lie close to the plane of their attached ring [deviations = 0.107 (6) and 0.031 (6) Å]. In the crystal, the components are linked by O—H...O and O—H...N hydrogen bonds, generating [010] chains. C—H...O interactions are also observed.