Wiley, Annals of Neurology, 2(49), p. 260-263, 2001
DOI: 10.1002/1531-8249(20010201)49:2<260::aid-ana49>3.0.co;2-y
Wiley, Annals of Neurology, 2(49), p. 260-263
DOI: 10.1002/1531-8249(20010201)49:2<260::aid-ana49>3.3.co;2-p
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Status epilepticus is commonly refractory to first-line therapy, and thus better treatments are needed. We have investigated an experimental model of drug-resistant self-sustaining status epilepticus (SSSE) induced by 2 hours of perforant path stimulation. Propofol in subanesthetic doses administered shortly after the end of stimulation and also after a further 3 hours of SSSE terminated the SSSE without recurrence. This finding calls for a trial of propofol in refractory status epilepticus and also raises the possibility of using it as first-line therapy. Ann Neurol 2001;49:260–263