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National Academy of Sciences, Proceedings of the National Academy of Sciences, 16(95), p. 9190-9195, 1998

DOI: 10.1073/pnas.95.16.9190

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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

Journal article published in 1998 by Stefan Gaubatz ORCID, Jason G. Wood, David M. Livingston
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6 lacks pocket protein binding and transactivation domains, and it is a potent transcriptional repressor that contains a modular repression domain at its carboxyl terminus. Overproduction of E2F-6 had no specific effect on cell cycle progression in asynchronously growing Saos2 and NIH 3T3 cells, but it inhibited entry into S phase of NIH 3T3 cells stimulated to exit G 0 . Taken together, these data suggest that E2F-6 can regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression.