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Public Library of Science, PLoS ONE, 11(10), p. e0142388, 2015

DOI: 10.1371/journal.pone.0142388

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The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Journal article published in 2015 by Perminder S. Sachdev, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu ORCID, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C. M. Stephan, Richard B. Lipton, Mindy J. Katz, T. Hughes, Karen Ritchie, Isabelle Carrière, M. Zimmerman and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P