We evaluated the efficacy and side effects of herbal coded medicine, Dysonil, for the treatment of bacillary dysentery. Open randomized descriptive study was employed in this study. The drug Dysonil was prescribed to 48 patients while Metronidazole was prescribed to 45 patients who were registered at Shifa Ul Mulk Memorial Hospital. They all belong to villages around Hamdard University and urban population of Gadap Town area. The age range of patients was 12 to 35 years. The response of the treatment on symptomatology of bacillary dysentery was analysed. Dysonil was found to be an economical, safe and effective drug for bacillary dysentery treatment and was statistically significant at p<0.03.