GLEAM, the GaLactic and Extragalactic All-sky MWA survey, is a survey of the entire radio sky south of declination +25 deg at frequencies between 72 and 231 MHz, made with the Murchison Widefield Array (MWA) using a drift scan method that makes efficient use of the MWA's very large field-of-view. We present the observation details, imaging strategies and theoretical sensitivity for GLEAM. The survey ran for two years, the first year using 40 kHz frequency resolution and 0.5 s time resolution; the second year using 10 kHz frequency resolution and 2 s time resolution. The resulting image resolution and sensitivity depends on observing frequency, sky pointing and image weighting scheme. At 154 MHz the image resolution is approximately 2.5 x 2.2/cos(DEC+26.7) arcmin with sensitivity to structures up to ~10 deg in angular size. We provide tables to calculate the expected thermal noise for GLEAM mosaics depending on pointing and frequency and discuss limitations to achieving theoretical noise in Stokes I images. We discuss challenges, and their solutions, that arise for GLEAM including ionospheric effects on source positions and linearly polarised emission, and the instrumental polarisation effects inherent to the MWA's primary beam. ; Comment: 17 pages, 7 Figures, 4 tables. Accepted for publication in the Publications of the Astronomical Society of Australia (PASA)