Chromophobe renal cell carcinoma (CRCC) with neuroendocrine differentiation (CRCCND) has only recently been described. 18 cases of CRCC with morphologic features suggestive of neuroendocrine differentiation were selected from among 624 CRCC in our registry. The tissues were fixed in neutral formalin, embedded in paraffin, cut into 4 -5 μm thin sections and stained with Hematoxylin and Eosin (H&E). As CRCC with neuroendocrine features were suggested tumors with following morphology: 1, trabecular/palisading/ribbon-like, gyriform, insular, glandular and solid pattern. 2, uniform polygonal cells formed in small islets. 3, cribriform pattern in combination with palisading.