Published in
Elsevier, Atherosclerosis, 2(222), p. 360-366, 2012
DOI: 10.1016/j.atherosclerosis.2012.03.012
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits
Journal article published in 2012 by
Egon Demetz 
,
Ivan Tancevski,
Kristina Duwensee,
Ursula Stanzl,
Eva Huber,
Christiane Heim,
Florian Handle ,
Markus Theurl,
Andrea Schroll,
Anne Tailleux,
Hermann Dietrich,
Josef R. Patsch,
Philipp Eller,
Andreas Ritsch
,
Ivan Tancevski,
Kristina Duwensee,
Ursula Stanzl,
Eva Huber,
Christiane Heim,
Florian Handle ,
Markus Theurl,
Andrea Schroll,
Anne Tailleux,
Hermann Dietrich,
Josef R. Patsch,
Philipp Eller,
Andreas Ritsch
This paper is available in a repository.
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Abstract
► Small hairpin RNA specific for SR-BI nucleotides 214-232 reduces SR-BI expression in vitro. ► SiRNA treatment reduces liver expression of SR-BI in New Zealand White rabbits. ► Liver specific inhibition of SR-BI leads to a 50% reduction of atherosclerosis in cholesterol fed rabbits. ► The role of SR-BI in rabbits may be different from the one found in rodents.