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Public Library of Science, PLoS ONE, 2(9), p. e87982, 2014

DOI: 10.1371/journal.pone.0087982

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JMJD6 Regulates ERα Methylation on Arginine

Journal article published in 2014 by Coralie Poulard, Muriel Le Romancer, Juliette Rambaud, Nader Hussein, Laura Corbo, Muriel Le Romancer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ERα functions are tightly controlled by numerous post-translational modifications including arginine methylation, which is required to mediate the extranuclear functions of the receptor. We report that upon oestrogenic stimulation, JMJD6, the only arginine demethylase described so far, interacts with and regulates methylated ERα (metERα) function. Moreover, by combining the silencing of JMJD6 with demethylation assays, we show that metERα is a new substrate for JMJD6. We propose that the demethylase activity of JMJD6 is a decisive regulator of the rapid physiological responses to oestrogen.