Published in

Wiley Open Access, Journal of the International AIDS Society, 1(14), p. 42-42, 2011

DOI: 10.1186/1758-2652-14-42

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Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study

Journal article published in 2011 by Karin van der Merwe, Risa Hoffman, Vivian Black, Matthew Chersich, Ashraf Coovadia, Helen Rees ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Use of highly active antiretroviral therapy (HAART), a triple-drug combination, in HIV-infected pregnant women markedly reduces mother to child transmission of HIV and decreases maternal morbidity. However, there remains uncertainty about the effects of in utero exposure to HAART on foetal development. Methods Our objectives were to investigate whether in utero exposure to HAART is associated with low birth weight and/or preterm birth in a population of South African women with advanced HIV disease. A retrospective observational study was performed on women with CD4 counts ≤250 cells/mm 3 attending antenatal antiretroviral clinics in Johannesburg between October 2004 and March 2007. Low birth weight (