Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 13(17), p. 3676-3681
DOI: 10.1016/j.bmcl.2007.04.060
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Cytotoxic effects of C-glycosides in HOS and HeLa cell lines
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Abstract
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI50 values) below 10 μM, the C-glucopyranoside 38 being the most active against HeLa (5.4 μM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 μM). Some preliminary structure–activity relationships were established.