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American Academy of Neurology (AAN), Neurology, 5(84), p. 516-522, 2015

DOI: 10.1212/wnl.0000000000001215

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Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression

Journal article published in 2015 by Yun Kwok Wing, Siu Ping Lam, Jihui Zhang, Eric Leung, Chi Lai Ho, C. L. Ho, Sirong Chen, Man Ki Cheung, Shirley Xin Li, Joey Wing Yan Chan, Vincent Mok, Joshua Tsoh, Anne Chan, C. K. W. Ho, Crover Kwok Wah Ho
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

© 2015 American Academy of Neurology. Objective: To investigate dopamine transmission in patients with comorbid REM sleep behavior disorder (RBD) and major depressive disorder (MDD). Methods: This is a case-control study including 11 medicated patients with comorbid RBD and MDD (mean age 47.5 6 8.2), 8 medicated patients with MDD only (mean age 47.9 6 8.4), and 10 healthy participants (mean age 46.5 6 10.6 years). They underwent clinical assessment, video-polysomnography, olfactory tests, and neuroimaging studies ( 18 F-DOPA, 11C-raclopride, and 18 F-FDG PET neuroimaging). Results: Compared with the 2 control groups, patients with comorbid RBD and MDD had significantly lower 18 F-DOPA uptake at 60 minutes in the putamen and caudate after controlling for age and sex effect (p