Published in

American Academy of Neurology (AAN), Neurology, 4(65), p. 626-628, 2005

DOI: 10.1212/01.wnl.0000172930.63669.c8

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Botulinum toxin injections do not improve freezing of gait in Parkinson disease

Journal article published in 2005 by Marguerite Wieler, Richard Camicioli ORCID, C. Allyson Jones, W. R. Wayne Martin
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.