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Elsevier, Journal of Microbiology, Immunology and Infection, 6(50), p. 899-904, 2017

DOI: 10.1016/j.jmii.2015.12.009

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Fluconazole induces rapid high frequency MTL homozygosis with microbiological polymorphism in Candida albicans

Journal article published in 2016 by Tsong-Yih Ou, Fang-Mo Chang, Wei-Ning Cheng, Adela Lara, Ming-Li Chou, Wei-Fang Lee, Kai-Cheng Lee, Che-Tong Lin, Wen-Sen Lee, Fang-Lan Yu, Ching-Hua Su PhD Professor, Ching-Hua Su
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Candida albicans, a common fungal pathogen that can cause opportunistic infections, is regarded as an apparently asexual, diploid fungus. A parasexual cycle was previously found between homozygotes with opposite mating type-like loci (MTLa/α). Fluconazole-resistant strains had a higher proportion of MTL homozygotes, whereas MTL homozygous C. albicans was found in only about 3.2% of clinical strains. MTL heterozygotes had a low 1.4 x 10-4 frequency of white-opaque switching to MTL homozygotes in nature.