The experimental devices and conceptual designs of the field-reversed configuration (FRC), tandem mirror and spheromak as best solution for the low radioactive plasma, namely helium-3 based fusion plasma, are reviewed. Reactor schemes based on D-3 He-6 Li fuel with the possibility of 3 He mining on the Earth and Moon, including breeding and support reactors are proposed. 3 He acquisition, some estimation and resources are presented. Applications of D-3 He reactions and advanced-fueled alternative systems are discussed. PACS: 52.55.Lf.