American Society of Hematology, Blood, 8(126), p. 1005-1008, 2015
DOI: 10.1182/blood-2015-04-643361
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Key Points Somatic CDKN1B (p27) mutations were identified in 16% (13/81) of HCL patients and coexist with BRAFV600E mutations. CDKN1B is the second most common mutated gene in HCL implicating altered cell cycle regulation and/or senescence in HCL.