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American Society of Hematology, Blood, 1(126), p. 61-68, 2015

DOI: 10.1182/blood-2015-02-626846

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Hypermorphic mutation of phospholipase C,  2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Journal article published in 2015 by Ta-Ming Liu, Jennifer A. Woyach, Yiming Zhong, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A. Jones, Joseph Flynn, Leslie A. Andritsos, Kami Maddocks, Samantha M. Jaglowski, Kristie A. Blum and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points Hypermorphic PLCγ2 is independent of BTK activation. SYK or LYN inhibition antagonizes mutant PLCγ2-mediated signaling events.