Published in
American Society of Hematology, Blood, 2(126), p. 185-194, 2015
DOI: 10.1182/blood-2015-01-622704
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High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens
Journal article published in 2015 by
Julia Wegner,
Stephan Hackenberg,
Claus-Jürgen Scholz 
,
Sergey Chuvpilo,
Dmitry Tyrsin,
Alexey A. Matskevich,
Götz Ulrich Grigoleit,
S. Stevanovi,
Stefan Stevanović,
Thomas Hunig
,
Sergey Chuvpilo,
Dmitry Tyrsin,
Alexey A. Matskevich,
Götz Ulrich Grigoleit,
S. Stevanovi,
Stefan Stevanović,
Thomas Hunig
This paper is made freely available by the publisher.
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Abstract
Key Points CD8 memory T cells in PBMCs are antigen-hyporesponsive due to loss of priming by tissue-dependent interactions. Preculture at high cell density allows the detection of antiviral and antitumor responses that may be overlooked without this step.