Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL

Cui, Yongzhi; Onozawa, Masahiro; Garber, Haven R.; Samsel, Leigh; Wang, Ziyao; McCoy, J. Philip; Philip McCoy, J.; Burkett, Sandra; Wu, Xiaolin; Aplan, Peter D.; Mackall, Crystal L.

Published in

American Society of Hematology, Blood, 19(125), p. 2958-2967, 2015

DOI: 10.1182/blood-2014-10-609271

Tools

Export citation

Search in Google Scholar

Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL

Journal article published in 2015 by Yongzhi Cui, Masahiro Onozawa, Haven R. Garber

, Leigh Samsel, Ziyao Wang, J. Philip McCoy, J. Philip McCoy, Sandra Burkett

, Xiaolin Wu, Peter D. Aplan, Crystal L. Mackall

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving forbidden

Postprint: archiving restricted

Upload

Published version: archiving forbidden

Policy details

Data provided by

Abstract

Key Points Thymocyte signaling via a transgenic survivin-reactive TCR induced T-ALL with 100% penetrance. Thymic expression of signaling receptors targeting TAAs coexpressed in the thymus poses a risk for leukemogenesis.

Published in

Links

Tools

Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL

Abstract