Published in
American Society of Hematology, Blood, 16(125), p. 2568-2578, 2015
DOI: 10.1182/blood-2014-09-599480
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Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Journal article published in 2015 by
Claire S. Whyte 
,
Frauke Swieringa,
Tom G. Mastenbroek,
Ausra S. Lionikiene,
Marcus D. Lance ,
Paola E. J. van der Meijden,
Johan W. M. Heemskerk ,
Nicola J. Mutch
,
Frauke Swieringa,
Tom G. Mastenbroek,
Ausra S. Lionikiene,
Marcus D. Lance ,
Paola E. J. van der Meijden,
Johan W. M. Heemskerk ,
Nicola J. Mutch
This paper is made freely available by the publisher.
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Abstract
Key PointsUnder physiological flow rates, plasminogen primarily accumulates on fibrin(ogen), emanating from platelets and initiates fibrinolysis. Plasminogen is localized to defined “caps” on the surface of PS-exposing platelets in a fibrin(ogen)-dependent manner.