Published in
American Society of Hematology, Blood, 12(124), p. 1857-1867, 2014
DOI: 10.1182/blood-2014-05-574913
Links
- American Society of Hematology | PDF
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
Tools
Platelet bioreactor-on-a-chip
Journal article published in 2014 by
Jonathan N. Thon,
Linas Mazutis,
Stephen Wu,
Joanna L. Sylman,
Allen Ehrlicher,
Kellie R. Machlus 
,
Qiang Feng,
Shijiang Lu,
Robert Lanza,
Keith B. Neeves,
David A. Weitz,
Joseph E. Italiano
,
Qiang Feng,
Shijiang Lu,
Robert Lanza,
Keith B. Neeves,
David A. Weitz,
Joseph E. Italiano
This paper is made freely available by the publisher.
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Abstract
Key PointsWe have developed a biomimetic microfluidic platelet bioreactor that recapitulates bone marrow and blood vessel microenvironments. Application of shear stress in this bioreactor triggers physiological proplatelet production, and platelet release.