Published in
American Society of Hematology, Blood, 24(124), p. 3624-3635, 2014
DOI: 10.1182/blood-2014-04-566760
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Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice
Journal article published in 2014 by
Jose A. Guerrero 
,
Cavan Bennett ,
Louise van der Weyden,
Harriet McKinney,
Melody Chin,
Paquita Nurden,
Zoe McIntyre,
Emma L. Cambridge,
Jeanne Estabel,
Hannah Wardle-Jones,
Anneliese O. Speak,
Wendy N. Erber,
Augusto Rendon,
Willem H. Ouwehand,
Cedric Ghevaert
,
Cavan Bennett ,
Louise van der Weyden,
Harriet McKinney,
Melody Chin,
Paquita Nurden,
Zoe McIntyre,
Emma L. Cambridge,
Jeanne Estabel,
Hannah Wardle-Jones,
Anneliese O. Speak,
Wendy N. Erber,
Augusto Rendon,
Willem H. Ouwehand,
Cedric Ghevaert
This paper is made freely available by the publisher.
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Abstract
Key Points Proinflammatory MKs from mice with GPS drive the extension of myelofibrosis, splenomegaly, and emperipolesis. The lack of preformed α-granules in Nbeal2−/− platelets leads to protection against cancer metastasis.