Published in
American Society of Hematology, Blood, 10(124), p. 1597-1609, 2014
DOI: 10.1182/blood-2014-02-553834
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Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients
Journal article published in 2014 by
Bénédicte Neven,
Julie Bruneau 
,
Marie-Claude Stolzenberg,
Isabelle Meyts,
Aude Magerus-Chatinet,
Leen Moens,
Nina Lanzarotti,
Sandra Weller,
Denise Amiranoff,
Benoit Florkin,
Brigitte Bader-Meunier,
Guy Leverger,
Alice Ferster,
Christophe Chantrain,
Stéphane Blanche
and other authors.
,
Marie-Claude Stolzenberg,
Isabelle Meyts,
Aude Magerus-Chatinet,
Leen Moens,
Nina Lanzarotti,
Sandra Weller,
Denise Amiranoff,
Benoit Florkin,
Brigitte Bader-Meunier,
Guy Leverger,
Alice Ferster,
Christophe Chantrain,
Stéphane Blanche
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points ALPS predisposes to invasive bacterial infections, notably following splenectomy, and is associated with defective B-cell function. Poor anti-polysaccharide IgM antibody production and spleen MZ disorganization correlate with lymphoproliferation.