American Society of Hematology, Blood, 10(124), p. 1597-1609, 2014
DOI: 10.1182/blood-2014-02-553834
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Key Points ALPS predisposes to invasive bacterial infections, notably following splenectomy, and is associated with defective B-cell function. Poor anti-polysaccharide IgM antibody production and spleen MZ disorganization correlate with lymphoproliferation.