Published in
American Society of Hematology, Blood, 1(124), p. 121-133, 2014
DOI: 10.1182/blood-2013-11-538819
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SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
Journal article published in 2014 by
Daniel Sasca 
,
Patricia S. Hahnel,
Jakub Szybinski,
Kaml Khawaja,
Oliver Kriege,
Saskia V. Pante,
Lars Bullinger,
Susanne Strand,
Dennis Strand,
Matthias Theobald,
Thomas Kindler
,
Patricia S. Hahnel,
Jakub Szybinski,
Kaml Khawaja,
Oliver Kriege,
Saskia V. Pante,
Lars Bullinger,
Susanne Strand,
Dennis Strand,
Matthias Theobald,
Thomas Kindler
This paper is made freely available by the publisher.
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Abstract
Key Points SIRT1 is highly expressed in subsets of patients with acute myeloid leukemia harboring activating mutations in signaling pathways and is regulated at the protein levels. Targeting SIRT1 sensitizes leukemic blast to tyrosine kinase inhibitor treatment or chemotherapy via restoration of p53 activity.