Published in
American Society of Hematology, Blood, 7(122), p. 1174-1181, 2013
DOI: 10.1182/blood-2012-12-473843
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Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions
Journal article published in 2013 by
Line Mathiesen 
,
Leif K. Nielsen,
Jan Terje Andersen,
Algirdas Grevys ,
Inger Sandlie,
Terje E. Michaelsen,
Morten Hedegaard,
Lisbeth E. Knudsen,
Morten Hanefeld Dziegiel
,
Leif K. Nielsen,
Jan Terje Andersen,
Algirdas Grevys ,
Inger Sandlie,
Terje E. Michaelsen,
Morten Hedegaard,
Lisbeth E. Knudsen,
Morten Hanefeld Dziegiel
This paper is made freely available by the publisher.
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Abstract
Key Points Retained FcRn binding of an IgG3 antibody devoid of FcgR and C1q binding, cellular cytotoxicity and complement activation. Inhibition of pathogenic polyclonal anti-D in antibody-dependent cellular toxicity by a hinge region deleted anti-D IgG3 antibody with efficient transplacental transport capacity.