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Wiley-VCH Verlag, ChemInform, 44(31), p. no-no, 2000

DOI: 10.1002/chin.200044107

Elsevier, Bioorganic and Medicinal Chemistry Letters, 14(10), p. 1609-1612

DOI: 10.1016/s0960-894x(00)00293-6

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The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives

Journal article published in 2000 by Paul Kong Thoo Lin, Valentin A. Pavlov ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Bis-naphthalimidopropyl putrescine (BNIPPut), spermidine (BNIPSpd), spermine (BNIPSpm) and oxa-putrescine (BNIPOPut) were synthesised and their growth-inhibitory properties characterised. All these compounds except for BNIPOPut, showed high in vitro cytotoxic activity (with mean GI50 values between 0.5 and 8.45 microM) and selectivity against cancer cells derived from nine different human tumours. The increased content of nitrogen atoms in the linker chain of BNIPSpd and BNIPSpm significantly improved their aqueous dissolution properties with a marginal decrease in their cytotoxic activity.