The future evolutions on the dental materials should be directed to develop biomaterials capable of responding independently to the load specification of a dental restoration. The prevention of secondary caries, remineralization of dental tissue damage and preventing of its demineralization, are the main features that should exhibit a dental restorative material. In this context, we have developed Zinc phosphate cements in the ternary system Al2O3/ZnO/P2O5. These cements containing fluorides witch are broadcast after the restoration, in order to fulfiltheir role advocated in the prevention of caries. The antibacterial studies and kinetics of fluoride release by these cements are performed "in vitro". Thediffusionkinetics was studied on three sources of fluoride added to the cement powder in the form of fluoridated salt. Thecomparative study of kinetic models of each salt is evaluated. This has contributed to the choice of an optimum which hasa good kinetics profile. The antibacteriological evaluation is performed on samples of Zinc phosphate cements. This study has contributed to cariostatic effect control for these materials and to improve their biological performance.