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National Academy of Sciences, Proceedings of the National Academy of Sciences, 10(113), p. 2738-2743, 2016

DOI: 10.1073/pnas.1520376113

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Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions

Journal article published in 2016 by Ahmed Mahfouz ORCID, Boudewijn P. F. Lelieveldt, Aldo Grefhorst, Lisa T. C. M. van Weert ORCID, Isabel M. Mol, Hetty C. M. Sips, José K. van den Heuvel, Nicole A. Datson ORCID, Jenny A. Visser, Marcel J. T. Reinders ORCID, Onno C. Meijer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover ( i ) brain regions that respond in a similar manner to particular steroids, ( ii ) signaling pathways that are used in a steroid receptor and brain region-specific manner, and ( iii ) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.