National Academy of Sciences, Proceedings of the National Academy of Sciences, 10(113), p. 2738-2743, 2016
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Significance Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover ( i ) brain regions that respond in a similar manner to particular steroids, ( ii ) signaling pathways that are used in a steroid receptor and brain region-specific manner, and ( iii ) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.