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BioMed Central, Molecular Cancer, 1(15), 2016

DOI: 10.1186/s12943-016-0492-8

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Deregulated expression of cryptochrome genes in human colorectal cancer

Journal article published in 2016 by Gianluigi Mazzoccoli, Tommaso Colangelo, Anna Panza, Rosa Rubino, Angelo De Cata, Cristiana Tiberio, Maria Rosa Valvano, Valerio Pazienza, Giuseppe Merla, Bartolomeo Augello, Domenico Trombetta ORCID, Clelia Tiziana Storlazzi, Gemma Macchia, Annamaria Gentile, Francesca Tavano and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Circadian disruption and deranged molecular clockworks are involved in carcinogenesis. The cryptochrome genes (CRY1 and CRY2) encode circadian proteins important for the functioning of biological oscillators. Their expression in human colorectal cancer (CRC) and in colon cancer cell lines has not been evaluated so far. Methods We investigated CRY1 and CRY2 expression in fifty CRCs and in the CaCo2, HCT116, HT29, SW480 cell lines. Results CRY1 (p = 0.01) and CRY2 (p