We would like to acknowledge the anonymous reviewers for their critical comments that helped to improve the quality of the papers in this special issue. We would like to also acknowledge the organizers and committee members of The International Conference on Intelligent Biology and Medicine (ICIBM 2014, held on December 4–6, 2014) for their efforts to provide a forum to discuss integrative genomics and computational systems medicine, through which this special issue was made possible. We thank the National Science Foundation (NSF Grant IIS-1451135) and University of Texas Health Science at San Antonio for financial support of ICIBM 2014.