American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(51), p. 3449-3451, 2007
DOI: 10.1128/aac.01586-06
Full text: Download
ABSTRACT Growth-kill dynamics were characterized in vitro, and the parameter estimates were used to simulate bacterial growth and kill in vivo using both mouse and human pharmacokinetics. The parameter estimates obtained in vitro predicted a time above the MIC of between 35 and 38% for a static effect in mice after 24 h of treatment.