Published in
American Society of Hematology, Blood, 4(125), p. 658-667, 2015
DOI: 10.1182/blood-2014-04-571786
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net]
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BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
Journal article published in 2014 by
Cristina Correia,
Paula A. Schneider,
Haiming Dai,
Ahmet Dogan,
Matthew J. Maurer,
Amy K. Church,
Anne J. Novak,
Andrew L. Feldman 
,
Xiaosheng Wu,
Husheng Ding,
X. Wei Meng,
X. Wei Meng,
James R. Cerhan,
Susan L. Slager,
William R. Macon
and other authors.
,
Xiaosheng Wu,
Husheng Ding,
X. Wei Meng,
X. Wei Meng,
James R. Cerhan,
Susan L. Slager,
William R. Macon
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points BCL2 mutations in FL correlate with activation-induced cytidine deaminase expression and frequently alter the amino acid sequence of the protein. Mutations in the BCL2 coding sequence at diagnosis are associated with shortened time to transformation and earlier death due to lymphoma.