Integrated care of patients with COPD and comorbidities requires the ability to regard patient status as a complex system. It can benefit from technologies that extract multiparametric information and detect changes in status along different axes. This raises the need for generation of systems that can unobtrusively monitor, compute, and combine multiorgan information. In this paper, the concept and ongoing work for such an approach is presented as regards the multiple types of data recorded, features extracted, and examples of how they are combined in the EU-funded project WELCOME (Wearable Sensing and Smart Cloud Computing for Integrated Care to COPD Patients with Comorbidities) [1], for the integrated management of COPD and comorbidities.