Abstract Changes in bottom temperature, salinity, and density in the global ocean by 2100 for CMIP5 climate models are investigated for the climate change scenarios RCP4.5 and RCP8.5. The mean of 24 models shows a decrease in density in all deep basins, except the North Atlantic, which becomes denser. The individual model responses to climate change forcing are more complex: regarding temperature, the 24 models predict a warming of the bottom layer of the global ocean; in salinity, there is less agreement regarding the sign of the change, especially in the Southern Ocean. The magnitude and equatorward extent of these changes also vary strongly among models. The changes in properties can be linked with changes in the mean transport of key water masses. The Atlantic meridional overturning circulation weakens in most models and is directly linked to changes in bottom density in the North Atlantic. These changes are the result of the intrusion of modified Antarctic Bottom Water, made possible by the decrease in North Atlantic Deep Water formation. In the Indian, Pacific, and South Atlantic Oceans, changes in bottom density are congruent with the weakening in Antarctic Bottom Water transport through these basins. The authors argue that the greater the 1986–2005 meridional transports, the more changes have propagated equatorward by 2100. However, strong decreases in density over 100 yr of climate change cause a weakening of the transports. The speed at which these property changes reach the deep basins is critical for a correct assessment of the heat storage capacity of the oceans as well as for predictions of future sea level rise.