Medical science is one of the areas where mesoporous materials can offer important advances despite the stringent safety requirements for potentially useful materials. Here we report totally phospholipidic mesoporous particles which may be used as a novel drug carrier. This material is anticipated to be safe for human internal use since it is composed solely of phosphatidylcholine (PC) which is a major component of biological membranes and is approved for use in humans by the US Food and Drug Administration (FDA). We have established a simple production methodology of mesoporous phospholipid particles (MPPs) in which PC is dissolved in two-component solvent mixtures, followed by incubation of the resulting solutions at depressed temperatures, which induces liquid-liquid demixing and leads to the agglomeration of PC as spherical particles. A mesoporous form was then obtained by removing ice crystals through freeze-drying of the particles. MPP could accommodate both hydrophilic and hydrophobic guest molecules in the lamellar structure and the mesopores. It might be applied as a novel drug carrier in a complementary or even a replacement technology of liposomes.