American Association for the Advancement of Science, Science, 5588(297), p. 1867-1870, 2002
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Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123 + DCs. IDO + DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.