Bentham Science Publishers, Mini-Reviews in Medicinal Chemistry, 1(7), p. 31-38
DOI: 10.2174/138955707779317858
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Leptin, a peptide secreted by the white adipose tissue, circulates to the central nervous system and signals the status of body energy stores, regulating feeding behavior and energy balance. As human obesity is characterized by hyperleptinemia and leptin resistance, increasing leptin sensitivity is an attractive target for obesity treatment.