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Oxford University Press, Genetics, 4(196), p. 1227-1230, 2014

DOI: 10.1534/genetics.113.158808

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Exact vs. approximate computation: Reconciling different estimates of Mycobacterium tuberculosis epidemiological parameters

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Exact computational methods for inference in population genetics are intuitively preferable to approximate analyses. We reconcile two starkly different estimates of the reproductive number of tuberculosis from previous studies that used the same genotyping data and underlying model. This demonstrates the value of approximate analyses in validating exact methods.