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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 10-12(26), p. 1649-1652

DOI: 10.1080/15257770701506608

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Solid Phase Synthesis of Nucleobase and Ribose Modified Inosine Nucleoside Analogues

Journal article published in 2007 by Giorgia Oliviero, Jussara Amato, Stefano D'Errico, Nicola Borbone, Gennaro Piccialli ORCID, Luciano Mayol ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5'-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2' -3' ribose bond, furnished a set of new N-1 alkylated-2' -3' -secoinosine derivatives in high yields.