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Elsevier, Psychiatry Research, (236), p. 182-185

DOI: 10.1016/j.psychres.2016.01.017

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Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?

Journal article published in 2016 by Andrew Thompson, Steven Marwaha, Barnaby Nelson ORCID, Stephen J. Wood, Patrick D. McGorry ORCID, Alison R. Yung, Ashleigh Lin
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Abstract

We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate possible this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.