ABSTRACT FROM: Miklowitz DJ, O'Brien MP, Schlosser DA, et al. Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial. J Am Acad Child Adolesc Psychiatry 2014;53:848-58. What is already known on this topic? Transition to psychotic episode can be reduced to about 50% by psychosocial interventions such as cognitive behavioural therapy (CBT), but there are no improvements in negative symptoms and social functioning.1 ,2 Antipsychotic medications are not usually indicated unless the person meets criteria for a DSM-IV/ICD-10 psychotic disorder.3