Published in
Springer, Diabetologia, 6(53), p. 1190-1198, 2010
DOI: 10.1007/s00125-010-1689-9
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Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity.
Journal article published in 2010 by
Dr R. Webb,
K. Khunti,
R. Silverman,
Lj J. Gray,
B. Srinivasan,
Ps S. Lacy,
B. Williams 
,
Mj J. Davies
,
Mj J. Davies
This paper is made freely available by the publisher.
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Abstract
Non-invasive measures of aortic stiffness reflect vascular senescence and predict outcome in diabetes. Glucose-mediated elastic artery sclerosis may play an integral role in the development of macrovascular complications. We used carotid-femoral pulse wave velocity ((cf)PWV) to quantify independent associations of fasting glucose, post-challenge glucose and derived insulin resistance (HOMA-IR) with aortic stiffness.