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American Chemical Society, Journal of Medicinal Chemistry, 3(53), p. 1387-1391, 2010

DOI: 10.1021/jm901295s

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Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization

Journal article published in 2010 by Ramishetti Srinivas, Priya P. Karmali, Dipankar Pramanik, Yenugonda Venkata Mahidhar, Arup Garu, Yenugonda Venkata Mahidhar, Bharat K. Majeti, Sistla Ramakrishna, Gunda Srinivas, Arabinda Chaudhuri
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This paper is available in a repository.

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Abstract

Mannosylated cationic vectors have been previously used for delivering DNA vaccines to antigen presenting cells (APCs) via mannose receptors expressed on the cell surface of APCs. Here we show that cationic amphiphiles containing mannose-mimicking quinic acid and shikimic acid headgroups deliver genes to APCs via mannose receptor. Cationic amphiphile with shikimic acid headgroup was more efficacious than its mannosyl counterpart in combating mouse tumor growth by dendritic cell (the most professional APC) based genetic immunization.