Published in
American Association for the Advancement of Science, Science Translational Medicine, 283(7), 2015
DOI: 10.1126/scitranslmed.aaa4442
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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Journal article published in 2015 by
Ana Bosch,
Zhiqiang Li 
,
Anna Bergamaschi,
Haley Ellis,
Eneda Toska,
Aleix Prat,
Jessica J. Tao,
Daniel E. Spratt ,
Nerissa T. Viola-Villegas ,
Pau Castel ,
Gerard Minuesa,
Natasha Morse,
Jordi Rodon ,
Yasir Ibrahim,
Javier Cortes
and other authors.
,
Anna Bergamaschi,
Haley Ellis,
Eneda Toska,
Aleix Prat,
Jessica J. Tao,
Daniel E. Spratt ,
Nerissa T. Viola-Villegas ,
Pau Castel ,
Gerard Minuesa,
Natasha Morse,
Jordi Rodon ,
Yasir Ibrahim,
Javier Cortes
and other authors.
This paper is available in a repository.
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Abstract
Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer.