Published in
American Association for the Advancement of Science, Science Signaling, 386(8), 2015
DOI: 10.1126/scisignal.aac7862
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A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis
Journal article published in 2015 by
Anusha Ratneswaran,
Frank Beier 
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Abstract
Whether NOTCH signaling induces maintenance or degradation of joint cartilage depends on signal strength and duration.