Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response

Nairz, Manfred; Schroll, Andrea; Haschka, David; Dichtl, Stefanie; Sonnweber, Thomas; Theurl, Igor; Theurl, Milan; Lindner, Ewald; Demetz, Egon; Aßhoff, Malte; Aβhoff, Malte; Bellmann-Weiler, Rosa; Müller, Raphael; Gerner, Romana R.; Moschen, Alexander R.; Baumgartner, Nadja; Moser, Patrizia L.; Talasz, Heribert; Tilg, Herbert; Fang, Ferric C.; Weiss, Günter

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Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response

Journal article published in 2015 by Manfred Nairz, Andrea Schroll, David Haschka, Stefanie Dichtl, Thomas Sonnweber, Igor Theurl, Milan Theurl, Ewald Lindner, Egon Demetz

, Malte Aßhoff, Malte Aβhoff, Rosa Bellmann-Weiler, Raphael Müller, Romana R. Gerner, Alexander R. Moschen

and other authors.

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Abstract

Lipocalin-2 (Lcn2) is an innate immune peptide with pleiotropic effects. Lcn2 binds iron-laden bacterial siderophores, chemo-attracts neutrophils and has immunomodulatory and apoptosis-regulating effects.